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The present invention relates to a novel 6-aryl-5-(4-carboxamido-1-cyclohexen-1-yl)-3-pyridazinones, which are useful as inhibitors of phosphodiesterase type IV (PDE IV). The cyclic nucleotides cAMP and cGMP are second messengers present in most tissues. Changes in their cellular concentrations are important in controlling the number of key factors in cellular signal transduction, including second messengers, ion channels, and transcription factors. Cyclic nucleotides are produced by adenylyl cyclases (e.g., sGC, AC1, AC3) and guanylyl cyclases (e.g., GC-E, GC-G), and degraded by phosphodiesterases (PDEs). PDEs are a superfamily of enzymes encoded by 21 distinct genes (PDE1-PDE10A and PDE11A-PDE11K) in mammals. They are classified into 11 subfamilies according to their structure and function. The PDE10 subfamily comprises two genes, each encoding distinct proteins, PDE10A and PDE10B. PDE10A is highly expressed in the brain and various other tissues (see Toto, N. et al., Gene, 2001, 278, 7-14; Nakagawa, T. et al., Biochem. Biophys. Res. Commun., 2001, 284, 61-65; Park, J. et al., Neuroreport, 2001, 12, 2503-7; Oishi, Y. et al., Biochem. Biophys. Res. Commun., 2001, 284, 64-70; Sim, S. H. et al., Eur. J. Biochem., 2001, 268, 2755-2761; Lippman, M. B. et al., J. Biol. Chem., 2001, 276, 25302-25306; Wiese, H.-U. et al., Eur. J. Biochem., 2002, 269, 2418-2426; Hoffmann, K. et al., J. Biol. Chem., 2002, 277, 14303-14310; Choudhary, D. K. et al., Neuroreport, 2003, 14, 1058-1062; Choudhary, D. K. et al., J. Neurochem., 2003, 84, 466-476; Choud
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